Input Parameters | Distribution | Source (reference) |
---|---|---|
Outcome misclassification (information bias) | ||
Observed exposure: mercury concentration in cord blood (mg/L), | Meanx = 31.99, SDx = 25.53 | Budtz-Jorgensen et al. 2005; based on median and 99th percentile in a log-normal distribution (39) |
Observed outcome: Score on Boston naming test | Meany = 25, SDy = 5.3 | Mean: Grandjean et al. 1997 (4), SD from Budtz-Jorgensen et al. 2004 |
Observed b1 | N (-0.019, 0.0063) | Budtz-Jorgensen et al. 2005 (39) |
Observed b0 | = 25 - 31.99 × Observed b1 | Derived using standard linear regression formula (b0 = -b1 ) |
P1: proportion of exposed with a1 (negative) adjustment | U (0.1,0.3) | Hypothetical (no data available) |
P2: proportion of exposed with a2 (positive) adjustment | U (0.1,0.3) | Â |
a1: relative adjustment in outcome for proportion p1 of subjects | U (0.0,0.31) | Hypothetical (no data available), limits chosen to allow BNT score vary between 0 and 60 |
a2: relative adjustment in outcome for proportion p2 of subjects | U (0.0,0.48) | Â |
Selection bias | ||
---|---|---|
Observed exposure: mercury concentration in cord blood (mg/L), | See above | |
10,000 vectors (Meany, Sdy, b0, b1) adjusted for information bias | Output of Information Bias module | |
Number of subjects included in the analysis | 866 | Grandjean et al. 1997; N in Boston Naming Test "no cues" (4) |
Number of eligible subjects | 1362 | Calculated as 1022/0.75 (1022 are ~75% of all births (44) |
Number of subjects excluded from the analysis | 496 | Derived as 1362-866 |
Relative difference between mean exposure of subjects not included and mean exposure of included subjects | U (-5%,5%) | Hypothetical (no data available) |
Relative difference between mean outcome of subjects not included and mean outcome of included subjects | U (-10%,10%) | Hypothetical (no data available) |
Slope multiplier (to get to slope of non-included subjects) | U (0,2) | Hypothetical (no data available) |
Confounding | ||
---|---|---|
10,000 vectors (Meanx, SDx, Meany, SDy, b0, b1) adjusted for information and selection bias | Output of Selection Bias Module | |
Pearson correlation between confounder (WAIS) and exposure | U (-0.5, 0.5) | Hypothetical (no data available) |
Pearson correlation between confounder (WAIS) and outcome | U (0.2, 0.8) | Hypothetical (no data available) |