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Table 5 Results From Fitting Complete-Case and Multiple Imputation Models to Data from the Long Island Breast Cancer Study Project [19] Assessing the Effect of a Gene-Environment Interaction where m = 10

From: The use of complete-case and multiple imputation-based analyses in molecular epidemiology studies that assess interaction effects

Genotype/Alcohol Status

ORa CC

N = 2,063

(95% CI)

ORa MI

N = 3,064;m =10

(95% CI)

% Change in βCoefficient

Slow-Intermediate/Non-alcohol consumer

1.00

1.00

 

Fast/Non-alcohol consumer

1.18

(0.88, 1.58)

1.14

(0.88, 1.48)

22.11%

Slow-Intermediate/< 15 grams

1.16

(0.89, 1.50)

1.11

(0.89, 1.39)

25.38%

Fast/< 15 grams

0.92

(0.69, 1.23)

0.95

(0.75, 1.20)

30.89%

Slow-Intermediate/15-30 grams

1.49

(0.99, 2.25)

1.27

(0.89, 1.82)

40.23%

Fast/15-30 grams

2.32

(1.35, 4.01)

1.68

(1.03, 2.75)

38.68%

Slow-Intermediate/30+ grams

0.72

(0.43, 1.21)

0.77

(0.49, 1.19)

17.40%

Fast/30+ grams

0.98

(0.52, 1.87)

0.86

(0.47, 1.56)

> 100%

  1. CC = Complete Case; CI = Confidence Interval; MI = Multiple Imputation;OR = Odds Ratio
  2. aEstimates are adjusted for age at diagnosis, education, race, caloric intake, smoking status and body mass index