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Table 4 Impact of Nature of Missingness With Auxiliary Relationship Based on Data from LIBSCP.

From: The use of complete-case and multiple imputation-based analyses in molecular epidemiology studies that assess interaction effects

a. Subjects Missing Data on Genotype Under Conditions 1 and 3
Scenario Variable Method Mean β Mean SE Mean Bias MSE RelMSE Coverage
J:
Condition 1
Effect of Fast Metabolizing Genotype For Unexposed
(True effect = 1.0)
Full 1.001 0.155 0.001 0.025 0.738 95.1 (93.8,96.4)
   CC 0.999 0.182 -0.001 0.033 1.000 94.3 (92.9,95.7)
   MI 0.989 0.182 -0.011 0.032 0.954 95.0 (93.6,96.4)
  Effect of Fast Metabolizing Genotype For Exposed
(True effect = 2.5)
Full 2.508 0.157 0.008 0.025 0.664 94.3 (92.9,95.7)
   CC 2.519 0.197 0.019 0.037 1.000 96.4 (95.2,97.6)
   MI 2.090 0.193 -0.410 0.190 5.144 42.4 (39.3,45.5)
  Interaction Effect
(True effect = 1.5)
Full 1.507 0.220 0.007 0.049 0.684 94.7 (93.3,96.1)
   CC 1.520 0.268 0.020 0.072 1.000 95.5 (94.2,96.8)
   MI 1.101 0.265 -0.399 0.211 2.945 70.0 (67.2,72.8)
K:
Condition 3
        
  Effect of Fast Metabolizing Genotype For Unexposed
(True effect = 1.0)
Full 1.003 0.155 0.003 0.022 0.666 96.1 (94.9,97.3)
   CC 1.000 0.185 0.0002 0.034 1.000 95.6 (94.3,96.9)
   MI 1.004 0.191 0.004 0.032 0.978 95.6 (94.3,96.9)
  Effect of Fast Metabolizing Genotype For Exposed
(True effect = 2.5)
Full 2.509 0.157 0.010 0.024 0.024 95.9 (94.7,97.1)
   CC 3.463 0.233 0.963 0.983 1.000 0.2 (-0.1,0.5)
   MI 2.611 0.274 0.111 0.041 0.042 99.8 (99.5,100.1)
  Interaction Effect
(True effect = 1.5)
Full 1.507 0.220 0.007 0.048 0.047 95.9 (94.7,97.1)
   CC 2.463 0.298 0.963 1.012 1.000 9.5 (7.7,11.3)
   MI 1.608 0.340 0.108 0.074 0.073 99.2 (98.6,99.8)
b. Subjects Missing Data on Alcohol Exposure Under Conditions 1 and 2
Scenario Variable Method Mean β Mean SE Mean Bias MSE RelMSE Coverage
L:
Condition 1
Effect of Fast Metabolizing Genotype For Unexposed
(True effect = 1.0)
Full 1.016 0.155 0.016 0.025 0.962 94.7 (93.3,96.1)
   CC 1.015 0.158 0.015 0.026 1.000 95.4 (94.1,96.7)
   MI 1.308 0.150 0.308 0.115 4.502 45.6 (42.5,48.7)
  Effect of Fast Metabolizing Genotype For Exposed
(True effect = 2.5)
Full 2.504 0.156 0.004 0.022 0.737 96.2 (95.0,97.4)
   CC 2.503 0.189 0.003 0.039 1.000 94.1 (92.6,95.6)
   MI 2.449 0.183 -0.051 0.026 0.835 96.9 (95.8,98.0)
  Interaction Effect
(True effect = 1.5)
Full 1.488 0.220 -0.012 0.048 0.845 95.2 (93.9,96.5)
   CC 1.487 0.247 -0.013 0.056 1.000 96.4 (95.2,97.6)
   MI 1.141 0.247 -0.359 0.172 3.055 71.1 (68.3,73.9)
M:
Condition 2
Effect of Alcohol Exposure for Those without Fast Genotype (True effect = 0.5) Full 0.499 0.075 -0.001 0.006 0.622 95.5 (94.2,96.8)
   CC 0.501 0.095 0.001 0.009 1.000 94.6 (93.2,96.0)
   MI 0.560 0.095 0.060 0.012 1.348 91.4 (89.7,93.1)
  Effect of Alcohol Exposure for Those without Fast Genotype (True effect = 2.0) Full 2.008 0.176 0.008 0.032 0.780 94.4 (93.0,95.8)
   CC 2.006 0.202 0.006 0.041 1.000 95.1 (93.8,96.4)
   MI 1.621 0.199 -0.379 0.169 4.183 50.5 (47.4,53.6)
  Interaction Effect (True effect = 1.5) Full 1.509 0.192 0.009 0.037 0.743 95.2 (93.9,96.5)
   CC 1.505 0.223 0.005 0.050 1.000 95.6 (94.3,96.9)
   MI 1.061 0.217 -0.439 0.219 4.392 44.5 (41.4,47.6)
  1. Results From Fitting Full, Complete-Case, and Multiple Imputation Models to 1000 Simulated Data Sets With a Sample Size of 2058 Where the Covariate of Interest and as a Result the Interaction Term Were Missing for Approximately 20% of Subjects.